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مونوسیت
9 مهر 1390 ساعت 21:55 | نوشته ‌شده به دست tsha | ( نظرات 62 )

مونوسیت‌ها گویچه‌های سفیدی از سیستم ایمنی و از دسته آگرانولویست‌ها هستند که اندازه‌ای بین ۱۵ تا ۲۵ میکرون داشته، گرد یا بیضی هستند و شکل هسته آنها نامنظم ودارای پیچ خوردگی و گاهی کلیوی شکل است. مونوسیت‌ها بدون گرانول بوده یا دارای تعداد کمی گرانول ظریف هستند. سیتوپلاسم مونوسیت‌ها زیاد و آبی خاکستری و دارای دانه‌های ریز فلفلی به نام دانه‌های آزوروفیلیک هستند. سیتوپلاسم دارای پاهای کاذب می‌باشد. مونوسیت‌ها ممکن است حاوی واکوئل باشند.

مونوسیت‌ها بزرگترین سلول درجریان خون محسوب می‌شوند.

مونوسیت‌ها در مراحل اولیه واکنش ایمنی در فاگوسیتوز(سلول خواری)شرکت دارند.

منوسیت‌ها پس از خروج از خون و ورود به بافت‌های بدن به صورت سلول‌های درشتی به قطر ۸۰ میکرومتر به نام ماکروفاژ در می‌آیند در حقیقت منوسیت‌ها به وسیله پدیده‌ای به نام دیاپدز از منافذ رگ‌های خونی عبور می‌کنند و وارد بافت‌ها می‌شوند و تبدیل به ماکروفاژ می‌شوند.

مونوسیت‌ها، پروتئاز‌ها را از لیزوزوم‌ها آزاد می‌کنند. همچنین آنها رادیکال اکسیژن واکسید نیتروژن تولید می‌کنند که عوامل عفونی زا را از بین می‌برند. مونوسیت‌ها همچنین سیتوکین تولید می‌کنند که لنفوسیت‌ها را فعال و روند التهاب را تحریک می‌کند.

بیماری‌ها

افزایش در صد مونوسیت‌های خون مونوسیتوز نامیده می‌شود.

یک مونوسیت در میان گویچه‌های قرمز

هسته منوسیت لوبیائی، کلیه‌ای یا به شکل مغز است. کروماتین هسته سلول ظریف، کم رنگ است. سیتوپلاسم این سلول زیاد وآبی روشن است. داخل سیتوپلاسم دانه‌های ریز فلفلی دیده می‌شود. گاهی داخل سیتوپلاسم منوسیت واکوئل مشاهده می‌شود



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